Search results for "Class C GPCR"

showing 3 items of 3 documents

Pharmacological comparison of rat and human melanocortin 3 and 4 receptors in vitro.

2002

Abstract The melanocortin 3 and 4 receptors are G-protein-coupled receptors found in the hypothalamus with important role in regulation of the energy balance. In this study, we performed pharmacological comparison of the rat and human melancortin (MC) 3 and MC4 receptors. We transiently expressed the genes for these receptors individually in a mammalian cell line and determined the binding affinities to several MSH peptides. The results showed no major difference between the rat and human MC3 receptors while the rat MC4 receptor had higher affinity to several peptides compared with the human MC4 receptor. NDP-, α-, β-, γ-MSH, ACTH(1–24), HS014 and MTII had from 5- to 34-fold higher affinity…

medicine.medical_specialtyPhysiologyClinical BiochemistryHypothalamusClass C GPCRBiologyLigandsBiochemistryBinding CompetitiveCellular and Molecular NeuroscienceChemokine receptorEndocrinologyMelanocortin receptorInternal medicinemedicineCyclic AMPAnimalsHumansACTH receptorReceptor5-HT receptor5-HT2 receptorCell biologyRatsEndocrinologyReceptors Corticotropinalpha-MSHCOS CellsReceptor Melanocortin Type 45-HT1 receptorProtein BindingReceptor Melanocortin Type 3Regulatory peptides
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Origin of neuronal-like receptors in Metazoa: cloning of a metabotropic glutamate/GABA-like receptor from the marine sponge Geodia cydonium.

1999

To date, no conclusive evidence has been presented for the existence of neuronal-like elements in Porifera (sponges). In the present study, isolated cells from the marine sponge Geodia cydonium are shown to react to the excitatory amino acid glutamate with an increase in the concentration of intracellular calcium [Ca2+]i. This effect can also be observed when the compounds L-quisqualic acid (L-QA) or L-(+)-2-amino-4-phosphonobutyric acid (L-AP-4) are used. The effect of L-QA and L-AP-4, both agonists for metabotropic glutamate receptors (mGluRs), can be abolished by the antagonist of group I mGluRs, (RS)-alpha-methyl-4-carboxyphenylglycine. These data suggest that sponge cells contain an mG…

HistologyMolecular Sequence DataGlutamic AcidClass C GPCRBiologyReceptors Metabotropic GlutamatePathology and Forensic MedicineMiceReceptors GABAAnimalsAmino Acid SequenceCloning MolecularSequence Homology Amino AcidMetabotropic glutamate receptor 4Metabotropic glutamate receptor 7Metabotropic glutamate receptor 6Cell BiologyRecombinant ProteinsPoriferaRatsKineticsDrosophila melanogasternervous systemBiochemistryMetabotropic glutamate receptorMetabotropic glutamate receptor 1CalciumMetabotropic glutamate receptor 3Metabotropic glutamate receptor 2Excitatory Amino Acid AntagonistsSequence AlignmentCell and tissue research
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Interactions between cholinergic and fibroblast growth factor receptors in brain trophism and plasticity

2014

Acetylcholine, acting on both nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs), plays a role in the regulation of synaptic plasticity, being involved in the regulation of cellular processes and cognitive functions, such as learning, memory and attention. Recently, G protein coupled receptors (GPCRs), including mAChRs, have been reported to transactivate tyrosine-kinase receptors (RTK), such as epidermal growth factor receptor (EGFR), and initiate their intracellular signaling. In this minireview we have first analysed the RTK transactivation mechanisms, involving cholinergic receptors, and thereafter the interplay between AChR and neurotrophic factor systems built up by FGF2 a…

Transcriptional Activationmedicine.medical_specialtyClass C GPCRG protein coupled receptorBiologyCholinergic AgonistsBiochemistrySynaptic plasticityTransactivationNicotinic receptorNeurotrophic factorsInternal medicinemedicineAnimalsHumansReceptors CholinergicProtein Interaction MapsReceptorMolecular BiologyG protein-coupled receptorTransactivationNeuronal PlasticityFibroblast growth factor receptor 1Muscarinic receptorBrainReceptor Protein-Tyrosine KinasesCell BiologyGeneral MedicineReceptors Fibroblast Growth FactorErbB ReceptorsEndocrinologyFGFR1Fibroblast growth factor receptorFGFR1; G protein coupled receptor; Muscarinic receptors; Nicotinic receptors; Receptor-receptor interaction; Synaptic plasticity; Transactivation; Tyrosine-kinase receptorsSignal transductionTyrosine-kinase receptorsNeuroscienceReceptor-receptor interactionSignal Transduction
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